eAMP

A single drop of eAMP amplifies the target signal up to 10 million times

SwiftDX Protein Colour
how it works

eAMP Mode of Action

eAMP molecules can be combined with a specific antibody to target the chosen antigen. Additional eAMP proteins specifically bind to the eAMP molecule preceding it, creating millions of available binding sites for visible molecules such as colloidal gold.

This exponentially boosts the sensitivity of antigen detection by up to 10 million times compared to direct colloidal gold binding alone.

SwiftDX Protein Mole
SwiftDx

Our Unique Value

Customise

eAMP (enhanced Amplification) is easily customised for the chosen target illness

Incorporate

Our technology is easily incorporated into existing assay formats and manufacturing processes

Detect

SwiftDx products allow the detection ultra-low levels of the biomarker of interest in a simple, standard lateral flow test format

Figure shows nitrocellulose (NC) strips that have had different components passed up them. The NC has target antigen printed in 8 different lines which decrease in concentration on a log10 scale. The left axis gives the quantity of antigen on each line. Right axis gives an indication of the amount of amplification beyond direct targeting of a gold conjugate to the antigen. NS eAMP cascade control shows that proteins can flow through without causing background if the specific binding partner is not present. Units: ng: nanogram; pg: picogram; fg: femtogram. Abbreviations: eAMP: enhanced amplification; NS: non-specific.
SwiftDX Protein Colour
The proof

Demonstration of Our Technology

This figure demonstrates how a single drop of eAMP amplifies the protein signal compared to traditional gold labelling. The more lines that are visible, the greater the amplification.

In comparison, the current standard (‘biotin amplification’) only amplifies the signal up to 100 times more than direct labelling alone. With the SwiftDx eAMP cascade, the signal is amplified up to 10 million times.

Figure shows nitrocellulose (NC) strips that have had different components passed up them. The NC has target antigen printed in 8 different lines which decrease in concentration on a log10 scale. The left axis gives the quantity of antigen on each line. Right axis gives an indication of the amount of amplification beyond direct targeting of a gold conjugate to the antigen. NS eAMP cascade control shows that proteins can flow through without causing background if the specific binding partner is not present. Units: ng: nanogram; pg: picogram; fg: femtogram. Abbreviations: eAMP: enhanced amplification; NS: non-specific.